Protein Crystallography - What's New
20 Apr 2010 - CSAR (Community Structure-Activity Resource) - This effort aims to improve docking
and scoring through participation of the entire scientific community. CSAR will disseminate
experimental datasets of crystal structures and binding affinities for diverse protein-ligand complexes.
20 Apr 2010 - A Post-doctoral position is available immediately to study the structure and function
of cytokine receptor complexes that play essential roles in the development and control of the
adaptive immune response. Mark R. Walter, Department of Microbiology, University of Alabama at
Birmingham (UAB).
20 Apr 2010 - Applications are being accepted for a tenure track position at the Assistant or
Associate Professor level in the Department of Biology, Faculty of Science, University of
Waterloo. Applicants should have a PhD and postdoctoral experience with a research record in
Macromolecular X-ray Crystallography.
20 Apr 2010 - Applications are invited for a Research Associate position in the Division of Molecular
Biosciences in the field of time resolved Laue X-ray crystallography of light sensitive proteins in
the group of Dr. Jasper van Thor (Imperial College).
20 Apr 2010 - Movies -visualization of the effects of the absence of various diffraction data to the
electron density.
20 Apr 2010 - 5th-10th September 2010, The BCA Summer School is a combined taught and
practical course intended primarily for students and researchers new to crystallography. Its aim is to
provide comprehensive training in the theory and practise of crystallography, and to promote the
exchange of experience and best practise within the British crystallographic community. (May 1
registration deadline)
20 Apr 2010 - A postdoctoral position at OpenEye Scientific Software, Inc. to work on structural
assessment and re-refinement of a large number of protein-ligand complex structures from a number
of pharmaceutical companies to be deposited with the Community Structure-Activity Resource
(CSAR) and the PDB.
14 Apr 2010 - A postdoctoral position is available in the Department of Biochemistry at Emory
University (Atlanta, GA). This position is aimed at understanding the structural and mechanistic
basis for the evolution of novel function within the steroid hormone receptors.
30 Mar 2010 - Genentech Research Associate/Senior Research Associate -
Biophysics/Biochemical Pharmacology; Responsibilities: This position will develop, optimize, validate
and execute Surface Plasmon Resonance (SPR as implemented with Biacore technology) assays
that monitor direct binding of small molecules to protein targets. The successful candidate will play a
key role in developing innovative SPR methods and applications, as well as applying SPR and other
biophysical techniques within multi-disciplinary drug discovery project team.
30 Mar 2010 - Recruiting individuals with extensive experience in molecular biology, protein
purification, crystallization and automation to join the Protein Production Core of the newly
established NIH-funded Enzyme Function Initiative (EFI). The goal of the EFI is to develop a
general sequence/structure-based strategy for facilitating the discovery of in vitro enzymatic
activities and in vivo physiological functions of uncharacterized enzymes discovered in genome
projects.
30 Mar 2010 - Dr. Ruth Brenk, Biological Chemistry and Drug Discovery, College of Life Sciences,
University of Dundee - looking for a highly motivated computational chemist to be part of a multi-
disciplinary team to apply molecular modeling methods towards the discovery and optimization of
inhibitors of key enzymes of gram-Negative pathogens. The post is available immediately.
30 Mar 2010 - A postdoc position in membrane protein structural biology is available in the
Biomolecular Research Laboratory (BMR) at the Paul Scherrer Institute, Switzerland.
12 Mar 2010 - A postdoctoral position is available for a skilled protein crystallographer interested in
challenging projects in the Hurley lab, NIDDK, NIH. We are seeking to understand the structure
and function of membrane-associated multiprotein complexes involved in protein and lipid trafficking.
11 Feb 2010 - Rigaku Automation, Inc., a subsidiary of Rigaku Americas Corporation, located in
Carlsbad, CA, is looking for a unique experienced business and marketing professional who
possesses strong scientific and communication skills.
8 Feb 2010 - The Division of Structural Biology at the Helmholtz Centre for Infection Research
in Braunschweig/Germany invites applications for the position of a Head of Junior Research
Group (tenure track); Area of research: Structural biology.
5 Feb 2010 - Macromolecular X-Ray Crystallography School at PennState: This dual module,
online and onsite course is designed to introduce the fundamentals to those wanting to start
crystallographic projects and to those interested in a basics refresher. On-line May 11-June 1.
5 Feb 2010 - A postdoctoral position is available to study the structure of diverse drug targets
in the laboratory of Dr. Barry Finzel in Department of Medicinal Chemistry at the University of
Minnesota Twin Cities Campus.
5 Feb 2010 - Three Year Postdoctoral Position in Protein-DNA Crystallography, Institute of
Biomedical and Biomolecular Sciences, University of Portsmouth, U.K.
22 Jan 2010 - Genentech is among the world’s leading biotech companies, with multiple therapies
on the market for cancer and other serious medical conditions. The following opportunity exists in
the South San Francisco, CA, headquarters: Scientist - Protein Biochemist/Crystallographer.
22 Jan 2010 - Graduate Course - Neutron Scattering techniques in Structural Biology Oak
Ridge TN, June 7 – June 11, 2010
5 Oct 2009 - NQ-Flipper - Validates and corrects asparagine and glutamine side-chain amide
rotamers in protein structures. An interactive Jmol applet highlights the most offending interactions
between atom pairs.
1 Oct 2009 - SDsearch - used to find chemical compounds for binding analysis from large vendor
collections with user-defined chemical properties and/or containing specified substructures.
28 Sept 2009 - added link to MACiE - a server that contains 223 fully annotated enzyme reaction
mechanisms (Janet Thornton). MACiE (Mechanism, Annotation and Classification in Enzymes)
contains novel tools for searching catalytic mechanisms.
28 Sept 2009 - A 3 years post-doctoral position is available (Institut Pasteur, Paris, France) to
work on the structural biology of DNA transfer systems used by Gram-positive bacteria during DNA
exchange processes such as conjugation and natural transformation.
28 Sept 2009 - The Northeastern Collaborative Access Team (NE-CAT), located at the Advanced
Photon Source near Chicago, is seeking applicants for a Postdoctoral Research Associate position.
In addition to opportunities to conduct independent and/or collaborative crystallographic research at
the nation's largest synchrotron light source facility, the primary responsibility of the incumbent will
be to enhance NE-CAT's beamline sample automounter program, including upgrades and
maintenance of the existing systems and providing training and support to users.
28 Sept 2009 - A post-doctoral position is available in the research group of Thilo Stehle at the
University of Tübingen. A major focus of our research is to define molecular mechanisms of
attachment and cell entry for viruses and other pathogens.
28 Sept 2009 - Research Assistant II position available at Vanderbilt in our Biochemistry
Department: Under limited supervision, set up, conduct experiments, and continue research projects
following protocols including the appropriate recording of data and reporting of standard or variant
results. Assist in other laboratory and research functions.
28 Sept 2009 - Two Postdoctoral Research Associates - Department of Biochemistry & Sir William
Dunn School of Pathology, Oxford University, to study the Notch pathway, a universally conserved
signal transduction system in metazoan organisms which plays a crucial role in many biological
processes, including cell fate determination during development, cell proliferation, apoptosis and
angiogenesis.
28 Sept 2009 - Laboratory of Structural Biology Brussels is looking for a motivated scientist to
collaborate in an ESA (European Space Agency)-research project on the crystallization of
biological macromolecules. The project aims at understanding nucleation and growth processes
occurring during crystallization of proteins. This is a Ph.D. student position.
28 Sept 2009 - Cambridge Univ. looking for a highly motivated postdoctoral research fellow to join
in developing novel fragment-based strategies to investigate the druggability of protein-protein
interfaces with respect to modulation by small molecules, and implications for drug design.
28 Sept 2009 - A post-doctoral position in Structural Biology at St. Jude Children's Research
Hospital is available for highly motivated applicants to study the structure and function of replication
proteins and their interaction with DNA.
23 Sept 2009 - A postdoctoral position is available for an experienced molecular
biologist/macromolecular crystallographer in the laboratory of Erik Johansson and Elisabeth Sauer-
Eriksson at Umeå University. The project involves structure-function studies of DNA polymerase
epsilon.
and scoring through participation of the entire scientific community. CSAR will disseminate
experimental datasets of crystal structures and binding affinities for diverse protein-ligand complexes.
20 Apr 2010 - A Post-doctoral position is available immediately to study the structure and function
of cytokine receptor complexes that play essential roles in the development and control of the
adaptive immune response. Mark R. Walter, Department of Microbiology, University of Alabama at
Birmingham (UAB).
20 Apr 2010 - Applications are being accepted for a tenure track position at the Assistant or
Associate Professor level in the Department of Biology, Faculty of Science, University of
Waterloo. Applicants should have a PhD and postdoctoral experience with a research record in
Macromolecular X-ray Crystallography.
20 Apr 2010 - Applications are invited for a Research Associate position in the Division of Molecular
Biosciences in the field of time resolved Laue X-ray crystallography of light sensitive proteins in
the group of Dr. Jasper van Thor (Imperial College).
20 Apr 2010 - Movies -visualization of the effects of the absence of various diffraction data to the
electron density.
20 Apr 2010 - 5th-10th September 2010, The BCA Summer School is a combined taught and
practical course intended primarily for students and researchers new to crystallography. Its aim is to
provide comprehensive training in the theory and practise of crystallography, and to promote the
exchange of experience and best practise within the British crystallographic community. (May 1
registration deadline)
20 Apr 2010 - A postdoctoral position at OpenEye Scientific Software, Inc. to work on structural
assessment and re-refinement of a large number of protein-ligand complex structures from a number
of pharmaceutical companies to be deposited with the Community Structure-Activity Resource
(CSAR) and the PDB.
14 Apr 2010 - A postdoctoral position is available in the Department of Biochemistry at Emory
University (Atlanta, GA). This position is aimed at understanding the structural and mechanistic
basis for the evolution of novel function within the steroid hormone receptors.
30 Mar 2010 - Genentech Research Associate/Senior Research Associate -
Biophysics/Biochemical Pharmacology; Responsibilities: This position will develop, optimize, validate
and execute Surface Plasmon Resonance (SPR as implemented with Biacore technology) assays
that monitor direct binding of small molecules to protein targets. The successful candidate will play a
key role in developing innovative SPR methods and applications, as well as applying SPR and other
biophysical techniques within multi-disciplinary drug discovery project team.
30 Mar 2010 - Recruiting individuals with extensive experience in molecular biology, protein
purification, crystallization and automation to join the Protein Production Core of the newly
established NIH-funded Enzyme Function Initiative (EFI). The goal of the EFI is to develop a
general sequence/structure-based strategy for facilitating the discovery of in vitro enzymatic
activities and in vivo physiological functions of uncharacterized enzymes discovered in genome
projects.
30 Mar 2010 - Dr. Ruth Brenk, Biological Chemistry and Drug Discovery, College of Life Sciences,
University of Dundee - looking for a highly motivated computational chemist to be part of a multi-
disciplinary team to apply molecular modeling methods towards the discovery and optimization of
inhibitors of key enzymes of gram-Negative pathogens. The post is available immediately.
30 Mar 2010 - A postdoc position in membrane protein structural biology is available in the
Biomolecular Research Laboratory (BMR) at the Paul Scherrer Institute, Switzerland.
12 Mar 2010 - A postdoctoral position is available for a skilled protein crystallographer interested in
challenging projects in the Hurley lab, NIDDK, NIH. We are seeking to understand the structure
and function of membrane-associated multiprotein complexes involved in protein and lipid trafficking.
11 Feb 2010 - Rigaku Automation, Inc., a subsidiary of Rigaku Americas Corporation, located in
Carlsbad, CA, is looking for a unique experienced business and marketing professional who
possesses strong scientific and communication skills.
8 Feb 2010 - The Division of Structural Biology at the Helmholtz Centre for Infection Research
in Braunschweig/Germany invites applications for the position of a Head of Junior Research
Group (tenure track); Area of research: Structural biology.
5 Feb 2010 - Macromolecular X-Ray Crystallography School at PennState: This dual module,
online and onsite course is designed to introduce the fundamentals to those wanting to start
crystallographic projects and to those interested in a basics refresher. On-line May 11-June 1.
5 Feb 2010 - A postdoctoral position is available to study the structure of diverse drug targets
in the laboratory of Dr. Barry Finzel in Department of Medicinal Chemistry at the University of
Minnesota Twin Cities Campus.
5 Feb 2010 - Three Year Postdoctoral Position in Protein-DNA Crystallography, Institute of
Biomedical and Biomolecular Sciences, University of Portsmouth, U.K.
22 Jan 2010 - Genentech is among the world’s leading biotech companies, with multiple therapies
on the market for cancer and other serious medical conditions. The following opportunity exists in
the South San Francisco, CA, headquarters: Scientist - Protein Biochemist/Crystallographer.
22 Jan 2010 - Graduate Course - Neutron Scattering techniques in Structural Biology Oak
Ridge TN, June 7 – June 11, 2010
5 Oct 2009 - NQ-Flipper - Validates and corrects asparagine and glutamine side-chain amide
rotamers in protein structures. An interactive Jmol applet highlights the most offending interactions
between atom pairs.
1 Oct 2009 - SDsearch - used to find chemical compounds for binding analysis from large vendor
collections with user-defined chemical properties and/or containing specified substructures.
28 Sept 2009 - added link to MACiE - a server that contains 223 fully annotated enzyme reaction
mechanisms (Janet Thornton). MACiE (Mechanism, Annotation and Classification in Enzymes)
contains novel tools for searching catalytic mechanisms.
28 Sept 2009 - A 3 years post-doctoral position is available (Institut Pasteur, Paris, France) to
work on the structural biology of DNA transfer systems used by Gram-positive bacteria during DNA
exchange processes such as conjugation and natural transformation.
28 Sept 2009 - The Northeastern Collaborative Access Team (NE-CAT), located at the Advanced
Photon Source near Chicago, is seeking applicants for a Postdoctoral Research Associate position.
In addition to opportunities to conduct independent and/or collaborative crystallographic research at
the nation's largest synchrotron light source facility, the primary responsibility of the incumbent will
be to enhance NE-CAT's beamline sample automounter program, including upgrades and
maintenance of the existing systems and providing training and support to users.
28 Sept 2009 - A post-doctoral position is available in the research group of Thilo Stehle at the
University of Tübingen. A major focus of our research is to define molecular mechanisms of
attachment and cell entry for viruses and other pathogens.
28 Sept 2009 - Research Assistant II position available at Vanderbilt in our Biochemistry
Department: Under limited supervision, set up, conduct experiments, and continue research projects
following protocols including the appropriate recording of data and reporting of standard or variant
results. Assist in other laboratory and research functions.
28 Sept 2009 - Two Postdoctoral Research Associates - Department of Biochemistry & Sir William
Dunn School of Pathology, Oxford University, to study the Notch pathway, a universally conserved
signal transduction system in metazoan organisms which plays a crucial role in many biological
processes, including cell fate determination during development, cell proliferation, apoptosis and
angiogenesis.
28 Sept 2009 - Laboratory of Structural Biology Brussels is looking for a motivated scientist to
collaborate in an ESA (European Space Agency)-research project on the crystallization of
biological macromolecules. The project aims at understanding nucleation and growth processes
occurring during crystallization of proteins. This is a Ph.D. student position.
28 Sept 2009 - Cambridge Univ. looking for a highly motivated postdoctoral research fellow to join
in developing novel fragment-based strategies to investigate the druggability of protein-protein
interfaces with respect to modulation by small molecules, and implications for drug design.
28 Sept 2009 - A post-doctoral position in Structural Biology at St. Jude Children's Research
Hospital is available for highly motivated applicants to study the structure and function of replication
proteins and their interaction with DNA.
23 Sept 2009 - A postdoctoral position is available for an experienced molecular
biologist/macromolecular crystallographer in the laboratory of Erik Johansson and Elisabeth Sauer-
Eriksson at Umeå University. The project involves structure-function studies of DNA polymerase
epsilon.
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