We are delighted to announce that the 5th International Conference on Structural Analysis of Supramolecular
Assemblies by Hybrid Methods will be held from March 10-14, 2010 in Lake Tahoe, California at the Granlibakken
Conference Center. We invite you to visit our Symposium website at: http://www.hybridmethods2010.com/index.html,
register for the Symposium, submit an abstract, encourage all other interested parties to attend, and display the
enclosed meeting poster.

This Symposium builds on a series of very successful previous meetings on the same theme from 2004-2008. As in
previous years, the overall goal is to illustrate the power of combining state of the art methods to tackle important
and challenging biological problems and to identify limitations and gaps in currently practiced hybrid methods. The
central premise is that gaining a comprehensive understanding of the highly sophisticated machines, complexes,
and organelles of the cell requires the coordinated application of a number of complementary biophysical
approaches (hybrid methods). New innovations at the 2010 meeting will include a special workshop on “Harnessing
Different Wavelengths of Electromagnetic Radiation”, which will feature the rapidly developing fields of
subdiffraction light microscopy and other emerging imaging techniques (e.g., X-ray tomography), as well as new
advances within more “traditional” hybrid approaches such as the interfaces between electron microscopy, X-ray
crystallography, and computational biology.  Featured topics will also include other biophysical methods, proteomics
and cell biology.

The meeting will be divided into seven Scientific Sessions
and one Special Methods Workshop

Session I: Hybrid Approaches to Macromolecular Filaments
Session II: Hybrid Approaches to Membrane Complexes
Session III: Hybrid Approaches to Dynamic Assemblies
Session IV: Computational Approaches to Hybrid Analyses
Session V: Hybrid Approaches to Global Analyses
Session VI: Hybrid Approaches to Cell Biology
Session VII: Hybrid Approaches to Nanomachines
Special Methods Workshop: Harnessing Different Wavelengths of Electromagnetic Radiation

We are fortunate to have recruited two outstanding Keynote Speakers: Stephen C. Harrison (Harvard) and Thomas
D. Pollard (Yale), as well as a great program of platform speakers who utilize multiple approaches to investigate a
variety of complex biological systems. Additional platform speakers and all of the speakers for the Special Methods
Workshop will be selected from submitted abstracts.

Sincerely yours,

The Organizing Committee: Wes Sundquist, Chair, Phoebe Stewart, Co-Chair, Dorit Hanein, Nobutaka Hirokawa,
Felix Rey, Alasdair Steven, and Bill Weis.
Rachel Bookman, Conference Secretariat.